Calamine Cream Ovelle (100ml). Calamine works by its counter-irritant effect. After application to the skin the calamine evaporates, which produces a cooling effect that helps distract you from the itch. Zinc oxide and calamine have similar properties. Calamine has mild astringent (causing the contraction of skin cells), antipruritic (relieves itching) and soothing actions. Zinc oxide is mildly astringent with covering, protective and cooling properties.. Works by its counter-irritant effect. After application to the skin the calamine evaporates. Produces a cooling effect that helps distract you from the itch. Calamine cream contains zinc oxide. Has a soothing effect and also has antiseptic properties. Help prevent infection from scratching. Calamine has mild astringent, antipruritic, and soothing actions.. Zinc oxide is mildly astringent with covering, protective and cooling properties