Canesten Combi Pessary & Cream Clotrimazole. This product is a complete treatment for vaginal thrush because it treats both the internal cause and external symptoms.. It contains:. an intravaginal cream in a pre-filled applicator, containing 500mg (10% w/w) Clotrimazole as the active ingredient, for treatment at the site of infection.. a tube of soothing cream, containing 2% w/w Clotrimazole, to start relieving the external itch immediately.. Clotrimazole is an antifungal agent which fights the cause of infections such as thrush.. Some women suffer from recurrent attacks of thrush. To reduce the frequency of these attacks, the sexual partner’s penis can be treated with the external cream as well, even if they have no symptoms of thrush.