Biofreeze Pain Relieving Spray 118ml. Biofreeze Cryotherapy for joint and muscle pain - Spray (118ml). Acts through cryotherapy, which consists of the application of cold to decrease inflammation and pain relief.  Cooling and consequent reheating of tissues stimulate the return of blood flow to affected areas, accelerating recovery.. Biofreeze produces the same cold feeling of ice, but unlike ice, allows movement during treatment.. Recommended in cases of arthritis, muscle stiffness, muscle strains, muscle fatigue, bruises and sprains.