Canesten Thrush Cream 2% Clotrimazole (20g). Canesten Thrush Cream relieves irritation of the vulva (vulvitis) which is caused by vaginal thrush (candidiasis). Although this cream provides relief from the external irritation caused by vaginal thrush, it cannot treat any internal (vaginal) cause of the infection. Ask your doctor or pharmacist to recommend a treatment for this.. The active substance is clotrimazole.. Each gram of cream contains 20mg clotrimazole (2% w/w).