Replens MD Pre Filled Applicators (6). Vaginal Dryness is usually associated only with menopause. Why? Because at that time oestrogen levels drop and one of oestrogen’s roles is to keep the lining of the vagina moist and healthy.. In addition to menopause, vaginal dryness can be associated with breastfeeding or taking oral contraceptives. It can also occur in response to douching, pelvic radiation, prolonged use of tampons, advanced endometriosis, and as a side effect of a variety of medications, including aromatase inhibitors used to treat breast cancer.. Excessive exercise, persistent emotional stress or past traumatic sexual experiences, diuretics such as alcohol and caffeine, cigarette smoking, certain allergy medications and antihistamines can also exacerbate an existing condition.